Ndr kinases regulate retinal interneuron proliferation and homeostasis

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Rassf5 and Ndr kinases regulate neuronal polarity through Par3 phosphorylation in a novel pathway.

The morphology and polarized growth of cells depend on pathways that control the asymmetric distribution of regulatory factors. The evolutionarily conserved Ndr kinases play important roles in cell polarity and morphogenesis in yeast and invertebrates but it is unclear whether they perform a similar function in mammalian cells. Here, we analyze the function of mammalian Ndr1 and Ndr2 (also know...

متن کامل

3-Adrenergic Receptors Regulate Retinal Endothelial Cell Migration and Proliferation*

Sympathetic nerves may play a role in vascular disorders of the eye. In the present study, we hypothesized that activation of 3-adrenergic receptors on retinal endothelial cells would promote migration and proliferation of these cells, two markers of an angiogenic phenotype. We show, for the first time, expression of 3adrenergic receptors on cultured retinal endothelial cells. Activation of the...

متن کامل

The Roles of NDR Protein Kinases in Hippo Signalling

The Hippo tumour suppressor pathway has emerged as a critical regulator of tissue growth through controlling cellular processes such as cell proliferation, death, differentiation and stemness. Traditionally, the core cassette of the Hippo pathway includes the MST1/2 protein kinases, the LATS1/2 protein kinases, and the MOB1 scaffold signal transducer, which together regulate the transcriptional...

متن کامل

TRPV4 and AQP4 Channels Synergistically Regulate Cell Volume and Calcium Homeostasis in Retinal Müller Glia.

Brain edema formation occurs after dysfunctional control of extracellular volume partly through impaired astrocytic ion and water transport. Here, we show that such processes might involve synergistic cooperation between the glial water channel aquaporin 4 (AQP4) and the transient receptor potential isoform 4 (TRPV4), a polymodal swelling-sensitive cation channel. In mouse retinas, TRPV4 coloca...

متن کامل

Cellular and Molecular Analysis of NDR and LATS Kinases in Dictyostelium

Ich versichere hiermit ehrenwörtlich, dass die vorgelegte Dissertation von mir selbständig und ohne unerlaubte Hilfe angefertigt ist. NdrA of Dictyostelium localizes to the centrosome and is required for efficient phagocytosis. Traffic, in press. cytokinesis in Dictyostelium discoideum. Dictyostelium discoideum by a SIN-related pathway. Eur. discoideum is regulated by a SIN-related pathway. of ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Scientific Reports

سال: 2018

ISSN: 2045-2322

DOI: 10.1038/s41598-018-30492-9